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We have developed a human decellularised tissue model of solid cancers to address the lack of preclinical cancer models that take into account the tumour extracellular matrix, a key driver of immunotherapy resistance.
Our Dynamic Ex Vivo Assays (DEVA) are run in a patient-derived scaffold which is re-seeded with various cell populations, including cancer cells, macrophages, T Cells and fibroblasts. These assays are currently available for triple negative breast cancer and high grade serous ovarian cancer.
DEVA supports mono- and multicellular cultures. These can include cancer cell lines, macrophages, T Cells, fibroblasts, bacteria and more.
Our tissues maintain the ECM composition and immunosuppressive features of the TME.
We have omics data sets, IHC analysis and biophysical data from our tissues to complement the results from our assays.
DEVA is run in a 96 well plate, can be set up immediately, and is cheaper to run than even simple in vivo studies
Our unique (patent-pending), non-invasive, cytotoxicity assays provide cell type specific cell killing data
With DEVA you can quantify the therapeutic degradation of specific ECM components as well as analyse structural changes of the matrix
Cells are not static within a tumour. With DEVA cell movement is tracked in real-time and measure the speed, direction and co-localisation of cells
Created by David Moench
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